Colbert County Alabama is a beautiful area with a deep history dating back to the Cherokee and Chickasaw Indians and the early French traders around 1715. These early residents and settlers were attracted by the Tennessee River; the section in Colbert County earned the name “Muscle Shoals” because of the strength of the river in this area and the several different species of mussels. Colbert County has a population of 54,428. The county seat is Tuscumbia Alabama. Colbert County gets its name is in honor of brothers George and Levi Colbert, Chickasaw Indian chiefs.