Tallassee (also “Talassee,” “Talisi,” “Tellassee,” and various similar spellings) is a prehistoric and historic Native American site in Blount County and Monroe County, Tennessee, in the southeastern United States. Tallassee was the southernmost of a string of Overhill Cherokee villages that spanned the lower Little Tennessee River in the 18th century. Although it receives scant attention in primary historical accounts, Tallassee is one of the few Overhill towns to appear on every major 18th-century map of the Little Tennessee Valley.